Enrichment and analysis of secretory lysosomes from lymphocyte populations
نویسندگان
چکیده
منابع مشابه
Regulating secretory lysosomes.
Secretory lysosomes are lysosomes which are capable of undergoing regulated secretion in response to external stimuli. Many cells of the immune system use secretory lysosomes to release proteins involved in their specialised effector mechanisms. Precisely how lysosomal secretion is regulated in each of these cell types is now the study of much research as these mechanisms control the ability of...
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Cytotoxic T lymphocytes (CTL) contain granules that are exocytosed during specific interaction with target cells (TC). In this process, the granule contents, including the lethal protein perforin, as well as granzymes, a family of serine esterases, are delivered to the TC. Information regarding the routing of these proteins towards the granule and their exact localization within the granule is ...
متن کاملEnrichment of bis-(monoacylglyceryl) phosphate in lysosomes from rat liver.
The subcellular distribution in rat liver of a phospholipid identified as bis-(monoacylglyceryl) phosphate (bis(MAG)P) has been investigated. In liver from untreated animals, 48 % of bis(MAG)P was recovered in a crude mitochondrial fraction where it was enriched 2.8-fold over the homogenate in terms of protein. When liver from animals who had received Triton WR-1339 by injection 3 days earlier ...
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کاتالیست یک سنتز جدید برای تیواترها توصیف شده است. واکنش الکل ها با آریل، هتروآریل و آلکیل تیو ل ها درحضور 1،3،5- تری آزو- 2،4،6- تری فسفرین-2،2،4،4،6،6 هگزاکلراید ((tapc به عنوان یک کاتالیست موُثر، بازده های خوب تا عالی از تیواترها را حاصل می کند. علاوه براین، واکنش تحت شرایط بدون فلز و بدون حلال پیش می رود، بنابراین یک مکمل جالب برای روش های شناخته شده سنتز تیواترها ارائه می دهد. یک مکانیسم ا...
15 صفحه اولExcess secretory products fuse with lysosomes
Excess secretory products fuse with lysosomes ells known to spew secretory protein granules had been helpful in deciphering and defining the secretory pathway. But what happened when secretion systems were turned off? Lysosomes were known to degrade foreign proteins taken up by cells and even autodigest intracellular membranous structures—but what was the fate of excess endogenous protein? To a...
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ژورنال
عنوان ژورنال: BMC Immunology
سال: 2009
ISSN: 1471-2172
DOI: 10.1186/1471-2172-10-41